Advances in new benzimidazole formulations and their anti- Echinococcus activities
10.3760/cma.j.cn231583-20201106-00287
- VernacularTitle:苯并咪唑类药物新剂型及其抗棘球蚴活性研究进展
- Author:
Haishan YANG
1
;
Jie SHUANG
;
Yongzhen LI
Author Information
1. 青海大学医学院基础医学研究中心，西宁 810016
- Keywords:
Echinococcosis;
Benzimidazoles;
Physicochemical property;
New formulations;
Drug therapy
- From:
Chinese Journal of Endemiology
2021;40(6):507-512
- CountryChina
- Language:Chinese
-
Abstract:
Echinococcosis is a serious zoonosis parasitic disease caused by the parasitic larva of Echinococcus. Surgical treatment, as the preferred treatment of echinococcosis, has disadvantages such as small scope of application, difficulty in complete resection, high postoperative recurrence rate and heavy burden on patients. Drug therapy is not only a necessary supplement to the preoperative, intraoperative and postoperative treatment of echinococcosis patients, but also the first choice when surgical treatment is not applicable. This article reviews the physicochemical and pharmacokinetic properties of benzimidazole drugs, and summarizes the anti- Echinococcus activities of different benzimidazole formulations, it will provide a reference for future exploration of echinococcosis treatment drugs.
