Advances on the pathogenesis and treatment of disseminated intravascular coagulation in children with acute leukemia
10.3760/cma.j.cn101070-20200417-00669
- VernacularTitle:儿童急性白血病并弥散性血管内凝血的发病机制及治疗进展
- Author:
Ying YANG
1
;
Tianyou WANG
;
Suyun QIAN
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院重症医学科，北京 100045
- Keywords:
Acute leukemia;
Disseminated intravascular coagulation;
Child;
Pathogenesis;
Treatment
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(18):1438-1440
- CountryChina
- Language:Chinese
-
Abstract:
Disseminated intravascular coagulation (DIC) is a common and critical complication in children with acute leukemia.Acute promyelocytic leukemia (APL) is the most-common subtype of acute leukemia complica-ted with DIC.Although all-trans retinoic acid plus chemotherapy has significantly improved the overall survival of children with APL, the incidence of DIC-induced early mortality has not been improved.This review summarizes the advances on the pathogenesis and treatment of DIC in children with acute leukemia, aiming to provide evidences for clinical management.
