Detection of p16/Ki-67 in women with abnormal cytological results and its diagnostic value for cervical intraepithelial neoplasia II+ grade
10.3760/cma.j.cn121382-20210216-00403
- VernacularTitle:p16/Ki-67双染在细胞学结果异常人群中的检测及其对宫颈CIN2+病变的诊断价值
- Author:
Yanning XU
1
;
Ling CHEN
;
Yan SHEN
;
Xiaojing ZHANG
;
Xinying ZHANG
;
Yixin LIU
Author Information
1. 天津市中心妇产科医院南开大学附属妇产医院病理科，天津人类发育与生殖调控重点实验室 300100
- Keywords:
Cervical intraepithelial neoplasia;
p16/Ki-67 double staining;
High risk human papillomavirus;
Thinprep cytologic test
- From:
International Journal of Biomedical Engineering
2021;44(4):272-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the detection capability of p16/Ki-67 double staining technique in women with various abnormal thinprep cytologic test (TCT) results and its diagnostic value for cervical intraepithelial neoplasia Ⅱ+ grade (CIN2+).Methods:A total of 225 women with abnormal TCT results, i.e. the atypical squamous cells of undetermined significance(ASC-US), in the Tianjin Central Hospital of Gynecology Obstetrics, Nankai University Affiliated Maternity Hospital from December 2018 to December 2019 were enrolled. p16/Ki-67 double staining were detected and compared with the high risk human papillomavirus (HR-HPV) and pathological results.Results:The positive rates of p16/Ki-67 double staining increased with cytologic and pathologic categories. For diagnosis of CIN2+, p16/Ki-67double staining (90.1%) was less sensitive than HR-HPV testing (98.2%)( P<0.05), but the specificity of p16/Ki-67 double staining (58.8%) was significantly higher than HR-HPV(21.6%) ( P<0.001). Conclusions:Compared with HR-HPV, p16/Ki-67 double staining has better effect on diagnosing CIN2+. p16/Ki-67 double staining can be considered as triaging method for management of ASC-US and LSIL patients, significantly reduce the colposcopy referral rate (nearly 50%), which has high clinical application value.
