Updates on the role of T lymphocytes in crescentic glomerulonephritis
10.3760/cma.j.issn.1673-4408.2021.07.004
- VernacularTitle:T细胞在新月体肾炎中作用的研究进展
- Author:
Pei ZHANG
1
;
Chunlin GAO
;
Zhengkun XIA
Author Information
1. 南方医科大学南京临床医学院（东部战区总医院）儿科 南京大学医学院附属金陵医院（东部战区总医院） 儿科 东南大学医学院第二临床医学院（东部战区总医院） 儿科，南京 210002
- Keywords:
T lymphocytes;
Crescent;
Crescentic glomerulonephritis;
Mechanism
- From:
International Journal of Pediatrics
2021;48(7):450-454
- CountryChina
- Language:Chinese
-
Abstract:
The formation of crescent is a typical pathological change characterized by a rapid deterioration of renal function.T lymphocytes are involved in the formation of crescent and the pathological progression of crescent nephritis.CD4 + and CD8 + cells in T lymphocyte subsets, and T cell costimulatory factors mediate immune responses in different ways.They participate in the occurrence, development and fibrosis of crescent, or delay their deterioration.In order to provide a new target for clinical treatment of crescent nephritis, we review the mechanism of T lymphocytes in the formation and development of crescentic body.
