Tumor microenvironment and immunotherapy of neuroblastoma
10.3760/cma.j.issn.1673-4408.2021.07.001
- VernacularTitle:神经母细胞瘤肿瘤微环境和免疫治疗的研究进展
- Author:
Hui XIAO
1
;
Yijin GAO
Author Information
1. 上海交通大学医学院附属上海儿童医学中心血液肿瘤科 200127
- Keywords:
Children;
Neuroblastoma;
Tumor microenvironment;
Immunotherapy;
Monoclonal antibody;
Adoptive cell therapy
- From:
International Journal of Pediatrics
2021;48(7):435-439
- CountryChina
- Language:Chinese
-
Abstract:
Neuroblastoma(NB)is one of the most common malignant tumors in children.The prognosis of patients with high-risk NB remains poor despite intensive multimodal treatments including surgery, chemotherapy, radiation therapy and autologous hematopoietic stem cell transplantation.Recently, with good therapy results in hematological malignant tumors, more attention has been paid to immunotherapy for solid tumors such as NB.However, the efficacy of immunotherapy for NB is not as good as that for other hematological malignancies, which may be related to the complex tumor microenvironment(TME)of solid tumors.In order to better understand the direction and future application of immunotherapy in NB, we review TME and current immunotherapy for NB.
