Research of epigenetics related to extracellular matrix remodeling in bronchopulmonary dysplasia
10.3760/cma.j.issn.1673-4408.2021.06.007
- VernacularTitle:细胞外基质重塑在支气管肺发育不良患儿肺泡发育异常过程中的作用
- Author:
Xuefeng YAO
1
;
Yanping XU
Author Information
1. 浙江大学医学院附属儿童医院，杭州 310052
- Keywords:
Bronchopulmonary Dysplasia;
Epigenetics;
DNA methylation;
MicroRNAs
- From:
International Journal of Pediatrics
2021;48(6):391-396
- CountryChina
- Language:Chinese
-
Abstract:
Bronchopulmonary dysplasia(BPD)is a chronic pulmonary disease related to preterm neonatal.The pathogenesis of BPD hasn′t been clear now.But we have already known extracellular matrix remodeling has played an important role in alveoli dysplasia.We have found epigenetics has participated in extracellular matrix remodeling.There is a strict balance between the composition and decomposition of the ECM under the physiology state.However the ECM will reconstruct when its component change, which would influence the normal physiology process and lead to the disease.The review describes DNA methylation′s and microRNAs′ functions in extracellular matrix remodeling of BPD.This may help us understand the pathogenesis of BPD, and may offer some new methods to prevent or cure BPD.
