The mechanism of tumors as aging-related diseases
10.3760/cma.j.cn115356-20210714-00157
- VernacularTitle:肿瘤作为老年病的机制探讨
- Author:
Kefu WU
1
;
Guoguang ZHENG
;
Xiaotong MA
;
Yuhua SONG
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所） 实验血液学国家重点实验室 国家血液系统疾病临床医学研究中心，天津 300020
- Keywords:
Neoplasms;
Aging;
Immune system diseases;
Immunosenescence
- From:
Journal of Leukemia & Lymphoma
2021;30(10):577-580
- CountryChina
- Language:Chinese
-
Abstract:
The tumors originate from transformation cells caused by gene mutations. These cells are frequently kept at dormant state or detected and cleared by the immune surveillance. The research data show that the hallmarks of tumors and aging share many similarities, which is the biological basis for tumors as aging-related diseases. With the increase of tumor initiation cells and the decline of immune function in the elderly, the morbidity and mortality of tumors steadily increase. The core mechanisms are inflammaging and immunosenescence in the elderly. This article reviews recent advances in the field of tumorigenesis, inflammaging and immunosenescence, which elucidates the hypothesis and possible mechanism that tumors are aging-related diseases.
