Diagnostic criteria and research progress on lung allograft pathology
10.3969/j.issn.1674-7445.2022.01.004
- VernacularTitle:移植肺病理学诊断标准及其进展
- Author:
Hui GUO
1
Author Information
1. Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation of Ministry of Education, Key Laboratory of Organ Transplantation of National Health Commission of China, Key Laboratory of Organ Transplantation of Chinese Academy of Medical Sciences, Wuhan 430030, China
- Publication Type:Research Article
- Keywords:
Chronic obstructive pulmonary disease;
Cystic fibrosis;
Acute cellular rejection (ACR);
Antibody-mediated rejection (AMR);
T cell-mediated rejection (TCMR);
Transbronchial lung biopsy (TBLB);
Transbronchial cryobiopsy (TBCB);
Bronchoalveolar lavage;
Obliterative bronchiolitis (OB);
Transplant-associated vasculopathy (TAV)
- From:
Organ Transplantation
2022;13(1):19-
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the quantity of lung transplantation has been gradually increased in China along with the accumulation of surgical techniques and postoperative management experience of lung transplantation. Multiple lung allograft complications may occur after lung transplantation, mainly including primary graft dysfunction (PGD) caused by ischemia-reperfusion injury (IRI) of the lung allograft, acute and chronic rejection, opportunistic infection or lymphoproliferative disorder of lymphoid tissues induced by the decrease of host immunity due to postoperative use of immunosuppressants, etc. The diagnosis of complications after lung transplantation mainly relies on biopsy of the lung allograft. In this article, the brief history of lung allograft pathology, main approaches and pathological processing techniques of lung allograft biopsy, major complications after lung transplantation and pathological diagnostic criteria were elucidated, aiming to provide reference for targeted management of these complications in clinical practice.
