Research progress of natural polysaccharides and their nano-sized drug delivery systems in regulating tumor microenvironment
10.16438/j.0513-4870.2021-0396
- VernacularTitle:天然多糖及其纳米递药系统调控肿瘤微环境的研究进展
- Author:
Tao HAN
1
;
Yan CHEN
2
;
Ding QU
2
Author Information
1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
2. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
- Publication Type:Research Article
- Keywords:
natural polysaccharide;
nano-sized drug delivery system;
immunoregulation;
tumor microenvironment;
anti-tumor
- From:
Acta Pharmaceutica Sinica
2021;56(12):3212-3223
- CountryChina
- Language:Chinese
-
Abstract:
Natural polysaccharides with good biocompatibility and unique tumor immunomodulatory activity are becoming an important adjuvant anticancer therapy in clinic. In the field of pharmaceutics, natural polysaccharides can be used as not only bioactive components but also drug delivery carriers, as well as tumor-targeted ligands. Besides, various novel drug delivery systems based on natural polysaccharides exhibit unique advantages in regulating tumor immune microenvironment. In this review, we summarize the progress on natural polysaccharides in tumor microenvironment (TME) regulation and the designs of nano-sized drug delivery system, and point out challenges of polysaccharide-based drug delivery systems in the future application, and also give the potential solutions for these issues.
