Anti-tumor nanoscale drug delivery systems based on photodynamic therapy
10.16438/j.0513-4870.2021-0371
- VernacularTitle:基于光动力学疗法抗肿瘤的纳米给药系统
- Author:
Xue-li JIA
1
;
Yi-jing LIU
2
;
Miao LI
1
;
Li-na DU
2
;
Yi-guang JIN
1
Author Information
1. Beijing Institute of Radiation Medicine, Beijing 100850, China
2. Beijing Institute of Radiation Medicine, Beijing 100850, China; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
- Publication Type:Research Article
- Keywords:
photodynamic therapy;
photosensitizer;
tumor-targeting;
nanocarrier;
combinational therapy
- From:
Acta Pharmaceutica Sinica
2021;56(12):3421-3430
- CountryChina
- Language:Chinese
-
Abstract:
Photodynamic therapy (PDT) is a therapeutic strategy by which photosensitizers are excited by specific light irradiation to produce singlet oxygen for killing the surrounding cells. The advantages of PDT include weak invasion, slight side effect, and low resistance. The advantages of nanoscale drug delivery systems (DDS) include tumor-targeting, sustained release, and environmental-sensitivity. The combination of PDT and nanoscale DDS would likely lead to tumor targeting of photosensitizers and enhance their antitumor effectiveness. This review discusses the mechanism of PDT, photosensitizer-loaded nanoscale formulations, the combination of PDT and other antitumor therapies, and summarizes the applications and prospects of anti-tumor nanoscale DDS based on PDT. This review is a useful reference for its clinical application.
