Research progress of Netrin-1 in eye diseases
10.3980/j.issn.1672-5123.2022.1.12
- VernacularTitle:Netrin-1在眼病中的研究进展
- Author:
Kong-Qian Huang
1
Author Information
1. <sup>1</sup>Guilin Medical College, Guilin 541199, Guangxi Zhuang Autonomous Region, China|<sup>2</sup>Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China
- Publication Type:Review
- Keywords:
Netrin-1;
corneal diseases;
diabetic retinopathy;
optic nerve hypoplasia;
age-related macular degeneration;
retinoblastoma
- From:
International Eye Science
2022;22(1):62-66
- CountryChina
- Language:Chinese
-
Abstract:
Netrin-1 is a neuronal axon guidance factor, a soluble protein secreted by the cell floor, and is among the most widely studied members of the Netrins family.Netrin-1 has the diversity of receptors, and its binding to different receptors can activate different biological effects, resulting in multiple functions. Recent studies have revealed that Netrin-1 is closely associated with neural axon guidance, inflammatory responses, neovascularization, apoptosis, and other responses. It can act not only in the central nervous system, but also in many systemic diseases such as those of the respiratory and cardiovascular systems, making it an important target for the treatment of these diseases. In the field of ophthalmology, Netrin-1 is closely associated with optic nerve hypoplasia(ONH), corneal disease, diabetic retinopathy(DR), age-related macular degeneration(ARMD), and retinoblastoma(RB), and has very promising applications in the prevention and treatment of these diseases. In this review, we will explore the association of Netrin-1 with ocular diseases and its role.
- Full text:202201012.pdf
