Collaterals Doctrine Guided Investigation into Traditional Chinese Medicine Pathogenesis and Clinical Treatment of Myocardial Fibrosis Following Acute Myocardial Infarction
10.13422/j.cnki.syfjx.20211047
- VernacularTitle:基于脉络学说指导的急性心肌梗死后心肌纤维化中医病机及临床治疗探讨
- Author:
Kang WANG
1
;
Li-ping CHANG
2
;
Yu-jie YIN
2
;
Zhen-hua JIA
1
Author Information
1. School of Graduate，Hebei University of Chinese Medicine，Shijiazhuang 050092，China
2. Key Disciplines of Cardio-cerebral Vessel Collateral Disease， National Administration of Traditional Chinese Medicine（TCM）， State Key Laboratory of Collateral Disease Research and Innovative of TCM， Hebei Yiling Pharmaceutical Research Institute，Shijiazhuang 050035，China
- Publication Type:Research Article
- Keywords:
collaterals doctrine;
acute myocardial infarction （AMI）;
myocardial fibrosis;
Qi deficiency and blood stasis;
collaterals obstruction;
dispersing and dredging;
Tongxinluo
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(12):189-195
- CountryChina
- Language:Chinese
-
Abstract:
Interventional or thrombolytic therapy for acute myocardial infarction （AMI） has the effect of opening occluded coronary arteries. However， due to no myocardial regurgitation， ischemia/reperfusion injury and microvascular structure and function destruction， leading to myocardial fibrosis following AMI， ventricular remodeling， and even cardiac failure may occur. Collaterals doctrine is used to guide the investigation into traditional Chinese medicine pathogenesis and clinical treatment of myocardial fibrosis following AMI. Consequently， it proposes the pathogenesis characteristic of "Qi deficiency and blood stasis， collaterals obstruction" and medication principle of "dispersing and dredging"， to develop the formula of Tongxinluo. Fundamental and clinical researches have demonstrated it can effectively protect the structure and function of myocardial microvascular endothelial cells， improve no reflow and reperfusion injury， and inhibit myocardial fibrosis after AMI， which further supports scientific value of the collaterals doctrine.
