Progress in Application of Population Pharmacokinetic and Pharmacodynamic Models in Research on Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20210748
- VernacularTitle:群体药代动力学和药效动力学模型在中药研究中的应用进展
- Author:
Tian-qian JIN
1
;
Yang CHU
2
;
Xiao-hui MA
2
;
He SUN
2
;
Jin YANG
1
Author Information
1. Research Centre of Pharmacokinetics，China Pharmaceutical University，Nanjing 211100，China
2. State Key Laboratory of Critical Technology in Innovative Chinese Medicine， Tasly Pharmaceutical Group Co. Ltd.，Tianjin 300410，China
- Publication Type:Research Article
- Keywords:
quantitative pharmacology;
population pharmacokinetic （PPK） model;
pharmacokinetic-pharmacodynamic （PK-PD） model;
PPK-PD model;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(13):226-233
- CountryChina
- Language:Chinese
-
Abstract:
In recent years， the role of quantitative pharmacological models in applicable population of drugs and dose optimization has been widely recognized. In order to improve the efficiency of clinical development and optimize clinical rational drug use， quantitative pharmacological models are being gradually introduced into the research of traditional Chinese medicine （TCM）. There are various types of quantitative pharmacological models， among which the following three models are commonly used：①Population pharmacokinetic （PPK） model， which is mainly used to explore the pharmacokinetic characteristics in different populations.②Pharmacokinetic-pharmacodynamic （PK-PD） model， which is used to reveal the internal relationship among dose， time and efficacy. ③PPK-PD model， which integrates both the characteristics of PPK model and PK-PD model. The paper summarizes the application of the above three models in TCM， and extracts the main ideas and methods of TCM model research， in order to provide reference for clinical research and rational use of TCM.
