Pseudoallergic Reactions of Xuebijing Injection and Its Rational Drug Use
10.13422/j.cnki.syfjx.20212522
- VernacularTitle:血必净注射液类过敏反应及合理用药方法
- Author:
Yan YI
1
;
Chun-ying LI
1
;
Yu-shi ZHANG
1
;
Yong ZHAO
1
;
Gui-ping ZHANG
2
;
Jia-yin HAN
1
;
Jing-zhuo TIAN
1
;
Lian-mei WANG
1
;
Chen PAN
1
;
Su-yan LIU
1
;
Ai-hua LIANG
1
Author Information
1. State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine （TCM）Injections， Key Laboratory of Beijing for Identification and Safety of TCM， Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences， Beijing 100700， China
2. Tianjin Chase Sun Pharmaceutical Co. Ltd.， Tianjin 301700， China
- Publication Type:Research Article
- Keywords:
Xuebijing injection;
adverse reaction;
pseudoallergic reaction;
rational administration of drug
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(5):77-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether the adverse reactions of Xuebijing injection (XBJJ) are mainly pseudoallergic reactions and explore the influencing factors of its pseudoallergic reactions. Method:Mouse model of pseudoallergic reaction was used to study the anaphylactoid reaction of XBJJ which at 0.5, 1 and 2 times of the highest clinical concentration. Next, we compared the differences in pseudoallergic reactions caused by XBJJ for different storage times after preparation. Specifically, XBJJ was prepared into different concentrations, stored for 10 minutes, 2.5 hours, 6 hours and 24 hours, and then injected into the tail vein of mice. Finally, three different injection speeds of 3 seconds, 45 seconds and 90 seconds were selected for XBJJ injection, and then the differences in the paeudoallergic reactions induced by XBJJ in mice under different injection speeds were compared. Result:XBJJ induces pseudoallergic reactions in mice when the drug concentration is higher than the clinically recommended concentration. Compared with storage for 10 minutes after preparation, the degree of pseudoallergic reaction in mice induced by the same concentration of XBJJ increased with the extension of storage time. In addition, when XBJJ was injected in 3 s (the injection rate was 0.083 mL·s-1), it produced the strongest pseudoallergic reaction. Conclusion:The adverse reactions induced by XBJJ are mainly pseudoallergic reactions. Excessive storage time after preparation and fast injection speed of XBJJ will lead to aggravation of pseudoallergic reactions in mice. When XBJJ is used clinically, it should strictly follow the usage, dosage, concentration, and drip rate recommended in the drug instruction manual. Rational drug use is of positive significance for improving the safety of XBJJ.
