Meta-analysis on Effect of Xuebijing Injection on Inflammatory Index and Immune Function in Patients with Acute Exacerbation of COPD
10.13422/j.cnki.syfjx.20210415
- VernacularTitle:血必净注射液对慢性阻塞性肺疾病急性加重期患者炎症指标及免疫功能影响的Meta分析
- Author:
Ye-hui LI
1
;
Wen ZHU
1
;
Xian-mei ZHOU
1
Author Information
1. Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing 210009，China
- Publication Type:Research Article
- Keywords:
chronic obstructive pulmonary disease;
acute exacerbation;
Xuebijing injection;
randomized controlled trial;
Meta-analysis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(8):188-195
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of Xuebijing injection on inflammatory indexes and immune function in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Method:PubMed，Cochrane Library，Embase，Wed of Science，CBM，CNKI，VIP and Wanfang Data Online Knowledge service platform were searched by computer，all of which were up to February 2020. After literature screening and quality evaluation by two researchers independently，relevant data were extracted and Meta-analysis was carried out by RevMan 5.3 software. Result:A total of 21 randomized controlled trials（RCT） were included，involving 1 618 patients. The results of Meta-analysis showed，Xuebijing injection adjuvant therapy was significantly better than the control group in total effective rate ［relative risk（RR）=1.20，95% confidence interval（CI）（1.14，1.27），P<0.000 01］，C-reactive protein（CRP）［standard mean difference（SMD）=-1.58，95% CI（-1.98， -1.19），P<0.000 01］，total white blood cell （WBC）［mean difference（MD）=-1.44，95% CI（-1.84，-1.04），P<0.000 01］，procalcitonin（PCT）［SMD=-0.57，95% CI（-0.74，-0.41），P<0.000 01］，interleukin-6（IL-6）［SMD=-1.51，95% CI（-2.07，-0.96），P<0.000 01］，percentage of neutrophils（N%）［MD=-5.35，95% CI（-7.13，-3.58），P<0.000 01］，and tumor necrosis factor-α（TNF-α）［SMD=-1.52，95% CI（-2.23，-0.81），P<0.000 1］， and had positive effects in regulating cellular immune disorders. Conclusion:Xuebijing injection combined with routine treatment can improve the immune function of AECOPD patients，reduce the number of inflammatory markers，neutrophils and CD8+ T cells， thus modulating the small airway microcirculation to promote inflammatory absorption and inhibit the progression of the disease， with high safety.
