Analysis of Animal Models of Allergic Conjunctivitis Based on Characteristics of Clinical Symptoms in Chinese and Western Medicine
10.13422/j.cnki.syfjx.20210106
- VernacularTitle:基于中西医临床病证特点的过敏性结膜炎动物模型分析
- Author:
Ze-qian WANG
1
;
Ming-zhuo CAO
1
;
Xiu-min LI
1
;
Ming-san MIAO
1
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Research Article
- Keywords:
allergic conjunctivitis;
Chinese and Western medicine;
clinical condition;
animal models
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(7):187-192
- CountryChina
- Language:Chinese
-
Abstract:
Allergic conjunctivitis （AC） is one of the most common eye diseases in ophthalmology， including type I allergies and type Ⅳallergies， which seriously affect the quality of life of patients. This article analyzes the current models of allergic conjunctivitis based on the characteristics of clinical symptoms of Chinese and Western medicine， including the types of animals selected， the characteristics of the models， and the analysis of the degree of agreement with the clinical symptoms of Chinese and Western medicine. It is concluded that most of the current AC model replication uses ovalbumin （OVA） induction method， ragweed pollen induction method. In recent years， animal models of fungal-inducible， compound 48/80-inducible， and murine allergic conjunctivitis have appeared， which are sensitized by the "systemic first and then local" method. Most of them have a high degree of coincidence with the characteristics of Western medicine symptoms， but there are certain gaps in the indicators of Chinese medicine， and there are also inconsistencies between the existing observation indicators and the diagnostic standards of Chinese medicine， resulting in unclear symptoms of Chinese medicine and irregular classification judgments. Therefore， To replicate the animal model with high clinical anastomosis of Chinese and Western medicine， further discussion and research are needed to better promote the research of allergic conjunctivitis.
