Complex Network Analysis of Xiyanping Injection in Treatment of Bronchitis Based on Real World
10.13422/j.cnki.syfjx.20211213
- VernacularTitle:基于真实世界的喜炎平注射液治疗支气管炎的复杂网络分析
- Author:
Ke-xin DONG
1
;
Wei WU
2
;
Zhi-fei WANG
1
;
Li-xun LI
1
;
Yun-yun YANG
3
Author Information
1. Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences， Beijing 100700，China
2. Wangjing Hospital，China Academy of Chinese Medical Sciences，Beijing 100102，China
3. Renmin University of China，Beijing 100872，China
- Publication Type:Research Article
- Keywords:
real world;
Xiyanping injection;
bronchitis;
Tabu search algorithm;
combined medication
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(19):175-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the group modules of Chinese medicine and western medicine for the treatment of bronchitis patients with Xiyanping injection based on the real world to provide references for the clinical treatment of bronchitis with Chinese medicine and western medicine. Method:Medical records of 13 874 patients with bronchitis treated by Xiyanping injection were extracted from 29 hospital information systems （HISs） in China，and complex network analysis was carried out using Tabu Search algorithm to obtain the substructure and associated information of core drug combination of Xiyanping injection for the treatment of bronchitis and to analyze clinical medication protocols. Result:Medication protocols for the pathogens of bronchitis are listed below： Xiyanping injection + cefuroxime for bacterial infection. Xiyanping injection + interferon for viral infection. Xiyanping injection + azithromycin for mycoplasma infection. According to the clinical symptoms and complications of bronchitis， the appropriate medication protocols were as follows： Xiyanping injection + ambroxol + Feilike mixture + ibuprofen for uncomplicated bronchitis. Xiyanping injection + ipratropium bromide + budesonide + salbutamol for asthmatic bronchitis. Xiyanping injection + mannitol + furosemide + phenobarbital + gangliosides + immunoglobulin for bronchitis complicated with viral encephalitis. Xiyanping injection + creatine phosphate sodium + vitamin C for bronchitis complicated with viral myocarditis. The combined medication of Chinese medicine for the treatment of bronchitis was adopted based on its characteristics of traditional Chinese medicine. Conclusion:The data of this study were derived from the real world. The combined medications protocols of Xiyanping injection targeting the clinical symptoms and complications of bronchitis were extracted and summarized. However， it is necessary to formulate an individualized medication protocol according to the specific condition.
