Correlations Between Severity of Heart Failure Related to Coronary Heart Disease of Qi Deficiency and Blood Stasis Syndrome and Biological Indexes
10.13422/j.cnki.syfjx.20211694
- VernacularTitle:冠心病心力衰竭气虚血瘀证严重程度与生物学指标的相关性
- Author:
Jing-jing WEI
1
;
Bin LI
2
;
Guang-cao PENG
2
;
Xin-lu WANG
2
;
Qi-fei ZHAO
2
;
Jian-ru WANG
2
;
Rui YU
2
;
Yong-xia WANG
2
;
Ming-jun ZHU
2
Author Information
1. Henan University of Chinese Medicine，Zhengzhou 450000，China
2. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
- Publication Type:Research Article
- Keywords:
coronary heart disease;
heart failure;
Qi deficiency and blood stasis syndrome;
biological indexes;
correlation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(19):97-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlations of the severity of heart failure related to coronary heart disease arising from Qi deficiency and blood stasis with cardiac function indexes， energy metabolism indexes， coagulation function indexes， and inflammatory factors， in order to provide a scientific basis for further research on the biological foundation of this disease. Method:Two hundred patients with heart failure related to coronary heart disease of Qi deficiency and blood stasis syndrome were collected and then classified into mild， moderate and severe groups according to their scores of Qi deficiency and blood stasis syndrome. Meanwhile， 40 healthy persons confirmed by physical examination during the same period were included into the control group. Such biological indexes as cardiac function indexes， energy metabolism indexes， coagulation function indexes， and inflammatory factors were determined in patients of each group for comparison. Then the Spearman rank correlation analysis was conducted to figure out the correlations between differential indexes and the severity of Qi deficiency and blood stasis syndrome， followed by the determination of risk factors for the severity of Qi deficiency and blood stasis syndrome by ordered logistic regression analysis. Result:The cardiac function indexes， energy metabolism indexes， coagulation function indexes， and inflammatory factors in patients with heart failure related to coronary heart disease arising from Qi deficiency and blood stasis varied significantly. There were significant statistical differences in the levels of N-terminal pro-B-type natriuretic peptide （NT-ProBNP）， 6-minute walk test （6MWT）， heart-type fatty acid-binging protein （H-FABP）， prothrombin time （PT）， activated partial thromboplastin time （APTT）， tumor necrosis factor-α （TNF-α）， and nitric oxide （NO） among the mild， moderate， and severe groups （P<0.05）. The severity of Qi deficiency and blood stasis syndrome was positively correlated with NT-ProBNP （r=0.144）， PT （r=0.173）， and APTT （r=0.144）， but negatively with 6MWT （r=-0.287）. The 6MWT［odds ratio（OR）=0.995， 95% confidence interval（CI） 0.991-0.998），P<0.01］ and APTT（OR=1.088，95%CI 1.021-1.157，P<0.01） were independent risk factors affecting the severity of heart failure related to coronary heart disease arising from Qi deficiency and blood stasis. Conclusion:The severity of heart failure related to coronary heart disease of Qi deficiency and blood stasis syndrome is closely related to NT-ProBNP， 6MWT， H-FABP， PT， APTT， TNF-α， and NO. Moreover， 6MWT and APTT can be used as independent risk factors to evaluate the severity of patients with heart failure related to coronary heart disease due to Qi deficiency and blood stasis.
