Advance in Neurogranin for Cognitive Impairment Second to Central Nervous System Diseases (review)
10.3969/j.issn.1006-9771.2020.03.012
- VernacularTitle:神经颗粒素对中枢神经系统疾病认知功能障碍作用的研究进展
- Author:
Jia-yong ZHANG
1
;
Wei-lin LIU
1
;
Li-dian CHEN
1
;
Jing TAO
1
Author Information
1. College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350122,China
- Publication Type:Research Article
- Keywords:
neurogranin;
synaptic plasticity;
cognitive impairment;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2020;26(3):325-329
- CountryChina
- Language:Chinese
-
Abstract:
Neurogranin (Ng), as a neuron-specific postsynaptic protein, is abundant in the cerebral cortex and hippocampus. Ng may alter the affinity with calmodulin through phosphorylation and redox, and participate in the calcium signal pathway through glutamate receptor, to regulate the information transfer and synaptic plasticity. Ng involves in the formation and encoding of memories in related brain regions and plays an important role in learning, memory and cognitive function. Ng is associated with cognitive decline in Alzheimer's disease and can be used as a synaptic biomarker for diagnosis. Cognitive dysfunction after stroke is associated with decrease of Ng expression in the brain. Ng is one of the sites of genetic variants associated with susceptibility to schizophrenia.
