Roles of Microglial Membrane Receptors in Alzheimer's Disease (review)
10.3969/j.issn.1006-9771.2020.01.011
- VernacularTitle:小胶质细胞膜受体在阿尔茨海默病中的作用
- Author:
Hua-wei LIN
1
;
Wei-lin LIU
1
;
Zhi-fu WANG
1
;
Jing TAO
1
;
Li-dian CHEN
1
Author Information
1. College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China
- Publication Type:Research Article
- Keywords:
Alzheimer's disease;
microglia;
receptor;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2020;26(1):62-66
- CountryChina
- Language:Chinese
-
Abstract:
β-amyloid (Aβ) plaque deposition, neurofibrillary tangles and neuroinflammation are important pathological features of Alzheimer's disease (AD). Microglial membrane receptors, such as triggering receptor expressed on myeloid cells 2, Toll-like receptors, complement system and scavenger receptor, play a key role that mediate neuroinflammatory responses, promote Aβ clearance and signal transduction.
