Advance in Minocycline for Spinal Cord Injury (review)
10.3969/j.issn.1006-9771.2019.10.006
- VernacularTitle:米诺环素对脊髓损伤治疗机制的研究进展
- Author:
Rong-bao YAN
1
;
Quan QI
1
;
Yang LIU
1
;
Peng ZHAO
1
;
Cheng-yong LI
1
;
Xun-yi YIN
1
Author Information
1. Department of Orthopedics, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China
- Publication Type:Research Article
- Keywords:
minocycline;
spinal cord injury;
mechanism;
clinical research;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2019;25(10):1146-1149
- CountryChina
- Language:Chinese
-
Abstract:
The treatment of spinal cord injury has been the research priorities in basic and clinical medicine. This article described the mechanism of minocycline in treating spinal cord injury, including antioxidant activity, reduction of apoptosis, anti-inflammatory activity and selective regulation of microglia activation, and recent advances in clinical trials of minocycline. Minocycline targets multiple secondary injury mechanisms to promote the recovery of spinal cord injury, and further basic and clinical research will maximize the efficacy of minocycline.
