Advance in Interleukin-6 in Central Nervous System (review)
10.3969/j.issn.1006-9771.2019.05.007
- VernacularTitle:白细胞介素6在中枢神经系统中的研究进展
- Author:
Qiu-yan LIU
1
;
Lei-hong ZHANG
1
;
Xiao-ming YU
1
;
Ai-yun YUAN
1
Author Information
1. Department of Neurological Rehabilitation, Qingdao Women and Children’s Hospital, Qingdao, Shandong 266034, China
- Publication Type:Research Article
- Keywords:
interleukin-6;
nerve;
synapse;
cognition;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2019;25(5):540-545
- CountryChina
- Language:Chinese
-
Abstract:
The central nervous system can produce a variety of neuroimmune factors including interleukin-6. This article reviewed the expression and signaling pathways of interleukin-6 and its receptors in the central nervous system, and advances in interleukin-6 in the regulation of central nervous system related diseases, cognitive behaviors and synaptic function, which suggested that interleukin-6 involves in various physiological or pathological functions in the central nervous system and affects central nervous system in multiple layers such as protein expression, signal transduction, neurological function, and synaptic transmission. Interleukin-6 is expected to be a biological marker in the specific state of the central nervous system. In addition, interleukin-6 can regulate the function of neurons and synapses and is an important molecule involved in synaptic transmission, synaptic plasticity, and learning and memory. Strengthening the research on the biological function and mechanism of interleukin-6 and timely regulating the interleukin-6 expression will provide a new perspective for the treatment of the central nervous system related diseases.
