Advance in Pericytes and Related Angiogenic Signaling Pathways after Cerebral Ischemia (review)
10.3969/j.issn.1006-9771.2019.00.002
- VernacularTitle:脑缺血后周细胞及相关血管生成信号通路的研究进展
- Author:
Di ZHANG
1
;
Ming-shu XU
2
;
Ying-jie ZHANG
2
;
Ai-fang CHENG
1
;
Hua-zong GUAN
1
Author Information
1. Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China
2. Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China
- Publication Type:Research Article
- Keywords:
cerebral ischemia;
pericytes;
endothelial cell;
angiogenesis;
neurovascular unit
- From:
Chinese Journal of Rehabilitation Theory and Practice
2019;25(5):534-539
- CountryChina
- Language:Chinese
-
Abstract:
Pericytes, endothelial cells (EC), astrocytes and extracellular space together constitute the blood-brain barrier. Pericytes and EC participate in the various regulations of blood-brain barriers through many mechanisms to maintain the stability of neurovascular units (NVU). The injury and repair of NVU involve a lot of signal transduction at molecular levels, and angiogenesis is primarily about the generation and maturation of EC and the supporting adhesion process of pericytes. This article briefly reviewed EC-related angiogenesis signaling pathways in pericytes after NVU ischemic injury.
