Advances in Drugs for Microglia Polarization after Ischemic Stroke (review)
10.3969/j.issn.1006-9771.2020.05.013
- VernacularTitle:调控缺血性脑卒中小胶质细胞极化的药物研究进展
- Author:
Du-ping DENG
1
;
Jin FAN
1
;
Xiao-long XIE
1
;
Ling-xin LI
2
Author Information
1. College of Health Care and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China
2. Department of Rehabilitation, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
- Publication Type:Research Article
- Keywords:
ischemic stroke;
microglia;
phenotype;
drugs;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2020;26(5):559-562
- CountryChina
- Language:Chinese
-
Abstract:
Microglia cells are activated after ischemic stroke, and polarized phenotypes of M1 and M2. Some drugs, such as fingolimod, 3-N-butylphthalide, curcumin, sildenafil, exendin-4, celastrol, omega-3 fatty acids, malibatol A, salidroside, etc., can transfer the polarization from M1 to M2, and may benefit the outcome of ischemic stroke.
