Frequency-dependent Alterations in Amplitude of Low-frequency Fluctuations in Resting-state Functional Magnetic Resonance Imaging of Post Stroke Aphasia
10.3969/j.issn.1006-9771.2021.05.001
- VernacularTitle:卒中后失语静息态脑功能成像亚频段低频振幅脑活动研究
- Author:
Xiao-lin LI
1
;
Min-jie XU
1
;
Yun CAO
1
;
Dan-li ZHANG
1
;
Xin SHU
1
;
Chang-ming LI
1
;
Yu-fan ZHOU
1
;
Yi-hai TAN
1
;
Zhong-jian TAN
1
;
Jing-ling CHANG
1
Author Information
1. Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
- Publication Type:Research Article
- Keywords:
post stroke aphasia;
amplitude of low-frequency fluctuation;
fractional amplitude of low-frequency fluctuation;
frequency-dependent alterations
- From:
Chinese Journal of Rehabilitation Theory and Practice
2021;27(5):497-503
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics of local brain neural activity in post stroke aphasia (PSA) patients in different frequency bands and the relationship between Western Aphasia Battery (WAB) scores and specific frequency bands. Methods:From March, 2015 to May, 2018, 15 PSA patients, and 15 healthy adults as controls matched for age, gender and education were recruited. They were assessed with WAB and scaned with resting-state functional magnetic resonance imaging. The amplitude of low-frequency fluctuation (ALFF) and fractional amplitude of low-frequency fluctuation (fALFF) on the frequency bands of 0.01-0.08 Hz, 0.027-0.073 Hz, and 0.01-0.027 Hz were calculated. The ALFF and fALFF in different frequency bands were extracted and the correlation with the WAB scores in the patients were analyzed. Results:On 0.01-0.08 Hz, ALFF increased in the right precentral gyrus in the patients. On 0.027-0.073 Hz, ALFF increased values in the right precentral gyrus, and fALFF decreased in the right cerebellar Crus2 region; fALFF in the right cerebellar Crus2 region negatively correlated with the scores of information content (r = -0.576, P = 0.025), auditory comprehension (r = -0.658, P = 0.008), repetition (r = -0.616, P = 0.014) and aphasia quotient (r = -0.611, P = 0.016) of WAB. On 0.01-0.027 Hz, the fALFF decreased in the left inferior parietal limbic gyrus, and positively correlated with the scores of information content (r = 0.538, P = 0.039) and aphasia quotient (r = 0.526, P = 0.044). Conclusion:Resting-state fALFF abnormalities in PSA patients are frequency-dependent, which associate with some frequency-specific neurofunctional alterations.
