Role of Y-box binding protein-1 in the development and progression of chronic liver diseases
10.3969/j.issn.1001-5256.2021.11.050
- VernacularTitle:Y-box结合蛋白1在慢性肝病发生发展中的作用
- Author:
Ting LIU
1
;
Xiaoli XIE
1
;
Huiqing JIANG
1
Author Information
1. Department of Gastroenterology, The Second Hospital of Hebei Medical University; Hebei Key Laboratory of Gastroenterology; Hebei Institute of Gastroenterology, Shijiazhuang 050000, China
- Publication Type:Reviews
- Keywords:
Y-Box-Binding Protein 1;
Liver Cirrhosis;
Carcinoma, Hepatocellular;
Liver Failure
- From:
Journal of Clinical Hepatology
2021;37(11):2715-2718
- CountryChina
- Language:Chinese
-
Abstract:
Chronic liver diseases have various etiologies and often have poor long-term prognosis in clinical practice. Y-box binding protein-1 (YB-1) is a multifunctional protein, and in-depth studies in recent studies have found that it plays a key role in the development and progression of chronic liver diseases such as liver fibrosis and hepatocellular carcinoma (HCC). This article summarizes the role of YB-1 in chronic liver diseases such as liver fibrosis, HCC (proliferation, apoptosis, metastasis, prognosis, and drug resistance), and liver failure, so as to provide a theoretical basis for the diagnosis and treatment of chronic liver diseases.
