Granulocytic sarcoma of the breast: A case report in Lao PDR
- Author:
Phaengvilay Xaysomphet
1
;
Bounleng Kousonh
1
;
Soulideth Vilayvong
1
;
Thitsamay Luangxay
1
;
Phetsamone Alrounlansy
1
;
Motoji Sawabe
2
;
Moosa Khalil
3
Author Information
1. Department of Pathology, Faculty of Medicine, University of Health Science, Vientiane, Lao P.D.R
2. Section of Molecular Pathology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan
3. Department of Pathology and Laboratory Medicine, University of Calgary, Alberta, Canada
- Publication Type:Journal Article
- Keywords:
Granulocytic sarcoma, immunohistochemistry study, fluorescence in situ hybridization, histopathology diagnosis.
- From:Lao Medical Journal
2021;12(12):74-77
- CountryLao People's Democratic Republic
- Language:English
-
Abstract:
Granulocytic sarcoma (GS) also known as myeloid sarcoma, chloroma, myeloblastoma, or
extramedullary myeloid tumor is a neoplasm composed of immature myeloid cells. The common sites
of involvement include bone, central nervous system, soft tissue, lymph nodes, and skin. The
involvement of GS in breast tissue is very rare. The incidence of breast GS is 2/1,000,000 in adults.
Those affected range in age from 16 to 72 years, with the mean age of 31 years. Primary, isolated, or
non-leukemic GS of the breast is defined when bone marrow biopsy confirms the absence of other
hematologic malignancy. We here report a case of granulocytic sarcoma of the left breast in a 33
year-old woman who presented with a breast mass. She was initially diagnosed as having diffuse
lymphoma, large cell type on Hematoxylin and eosin stain (H&E) histopathology. The tumor cells
were, however, strongly positive for myeloperoxidase (MPO), CD117, CD34, and CD43 but negative
for CD45, CD20, CD3, or cytokeratin. Although further clinical information, such as complete blood
count or aspiration biopsy of bone marrow tissue, was absent, we finally diagnosed this case as GS
by additional immunohistochemical study. What happened to the patient?
- Full text:11.Case report.pdf
