Successful Sirolimus Treatment of Multiple Visceral Kaposi's Sarcoma in a Renal Allograft Patient.
10.4285/jkstn.2012.26.4.293
- Author:
Min Hwan KIM
1
;
Myoung Soo KIM
;
Yoon Jin CHA
;
Kyoung Sook PARK
;
Beom Seok KIM
;
Soohyeoun LEE
Author Information
1. Division of Medical Oncology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. SOCMED@yuhs.ac
- Publication Type:Case Report
- Keywords:
Kidney transplantation;
Kaposi sarcoma;
Sirolimus
- MeSH:
Biopsy;
Cadaver;
Humans;
Kidney;
Kidney Transplantation;
Liver;
Lung;
Lymph Nodes;
Male;
Peritoneum;
Renal Dialysis;
Sarcoma, Kaposi;
Sirolimus;
Tacrolimus;
Transplantation, Homologous;
Transplants
- From:The Journal of the Korean Society for Transplantation
2012;26(4):293-298
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The use of immunosuppressant's increases the risk of developing malignancies in renal allograft patients. One of the most important malignancies, Kaposi's sarcoma, can cause mortality and graft failure among renal allograft patients. We report the case of a 39-year-old male diagnosed with multiple visceral Kaposi's sarcoma 6 months after a second cadaveric renal allograft. The patient's renal function was markedly deteriorated at admission and required hemodialysis initially. Radiologic studies revealed Kaposi's sarcoma in multiple lymph nodes, liver, lung, and peritoneum. The excisional biopsy of an inguinal lymph node confirmed this diagnosis. After diagnosis, tacrolimus treatment was gradually decreased, and sirolimus treatment initiated. The patient did not receive any chemotherapy or radiotherapy. The Kaposi's sarcoma lesions decreased dramatically (both in size and number) 1 month after sirolimus treatment, and kidney graft function improved. This case thus shows successful sirolimus treatment of visceral Kaposi's sarcoma in a renal allograft patient.
