Effects of the fermented Zizyphus jujuba in the amyloid β25-35 -induced Alzheimer's disease mouse model
- Author:
Min Jeong KIM
1
;
Ji Eun JUNG
;
Sanghyun LEE
;
Eun Ju CHO
;
Hyun Young KIM
Author Information
- Publication Type:Original Research
- From:Nutrition Research and Practice 2021;15(2):173-186
- CountryRepublic of Korea
- Language:English
-
Abstract:
RESULTS:In behavioral tests, deterioration was revealed in the short- and long-term learning and memory functions in the Aβ25-35 -injected control group compared to the normal group, indicating that Aβ25-35 injection impairs cognitive functions. However, administration of Zj and Zj-Y improved cognitive function in mice, as compared to the Aβ25-35 -injected control mice. In addition, the Aβ25-35 induced elevations of MDA and NO in the brain, kidney, and liver were suppressed after exposure to Zj and Zj-Y. Especially, Zj-Y showed stronger scavenging effect against MDA and NO, as compared to Zj.
CONCLUSIONS:Results of the present study indicate that Zj-Y exerts a protective effect on cognitive impairment and memory dysfunction, which is exerted by attenuating the oxidative stress induced by Aβ25-35 .
