Performance and Diagnostic Accuracy of Human Papillomavirus Testing on Self-Collected Urine and Vaginal Samples in a Referral Population
- Author:
Hyun-Woong CHO
1
;
Jin Hwa HONG
;
Kyung Jin MIN
;
Yung-Taek OUH
;
Seok Ju SEONG
;
Jun Hye MOON
;
Seong Hwan CHO
;
Jae Kwan LEE
Author Information
- Publication Type:Original Article
- From:Cancer Research and Treatment 2021;53(3):829-836
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:The study aimed to evaluate the diagnostic accuracy of polymerase chain reaction ‒based high-risk human papillomavirus (HPV) assays on self-collected vaginal and urine samples for detection of precancerous cervical lesions in referral population.
Materials and Methods:Women referred for colposcopy following abnormal cytology, were included this study. A total of 314 matched urine, vaginal, and cervical samples were collected. All samples were tested for HPV DNA using the RealTime HR-S HPV and Anyplex II HPV 28 assays. Primary endpoints were sensitivity for cervical intraepithelial neoplasia (CIN) 2+/CIN3+ and specificity forConclusion:The detection performance for hrHPV and CIN2+ on self-collected vaginal samples was comparable to that of clinician-collected cervical samples. On the other hand, HPV tests using urine were inferior to those using clinician-collected cervical samples in terms of detecting hrHPV and CIN2+.
