Relationship between the Diurnal Temperature Range and Wound Healing of Diabetic Foot: Animal Study
10.14193/jkfas.2020.24.4.142
- Author:
Sung Hun WON
1
;
Dong-Il CHUN
;
Jaeho CHO
;
In Keun PARK
;
Young YI
Author Information
1. Department of Orthopedic Surgery, Soon Chun Hyang University Seoul Hospital, Seoul, Korea
- Publication Type:Original Article
- From:Journal of Korean Foot and Ankle Society
2020;24(4):142-147
- CountryRepublic of Korea
- Language:English
-
Abstract:
Materials and Methods:Rats in the abnormal diurnal temperature group and control group were given a 10 mm sized full-thickness skin ulcer. Wound size progression was observed in both groups. H&E and Masson’s trichrome staining was performed at 14 days after wound formation, and the number of vessels per unit area and histology analysis were performed. The changes in the ulcer were measured through three dimensional cross-section area using INSIGHT® devices.
Results:The wound recovery period (granulation ingrowing) was 24 days in the abnormal diurnal temperature model and 20 days in the control group. The thickness of scar tissue was 402±23.19 μm in the control group and 424.5±36.94 μm in the diurnal temperature model. Neovascular formation was counted as 5.1±0.97 for the control group and 4.16±0.94 for the diurnal temperature model group.
Conclusion:Delayed and inferior diabetic wound healing was observed in the abnormal diurnal temperature group, which was characterized by greater diurnal variations than the typical growth environment.
