The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment.
10.1016/j.apsb.2021.02.008
- Author:
Hong ZHANG
1
;
Liwu FU
1
Author Information
1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Esophageal Cancer Institute, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
- Publication Type:Review
- Keywords:
4-HNE, 4-hydroxy-2-nonenal;
ALD, alcoholic liver disease;
ALDH2;
ALDH2, aldehyde dehydrogenase 2;
AMPK, AMP-activated protein kinase;
Acetaldehyde;
BCa, bladder cancer;
COUP-TF, chicken ovalbumin upstream promoter-transcription factor;
CRC, colorectal cancer;
CSCs, cancer stem cells;
Cancer;
Cancer therapy;
DFS, disease-free survival;
EC, esophageal cancer;
FA, Fanconi anemia;
FANCD2, Fanconi anemia protein;
GCA, gastric cancer;
HCC, hepatocellular carcinoma;
HDACs, histone deacetylases;
HNC, head and neck cancer;
HNF-4, hepatocyte nuclear factor 4;
HR, homologous recombination;
LCSCs, liver cancer stem cells;
MDA, malondialdehyde;
MDR, multi-drug resistance;
MN, micronuclei;
Metastasis;
NAD, nicotinamide adenine dinucleotide;
NCEs, normochromic erythrocytes;
NER, nucleotide excision repair pathway;
NF-κB, nuclear factor-κB;
NHEJ, non-homologous end-joining;
NRF2, nuclear factor erythroid 2 (NF-E2)-related factor 2;
NRRE, nuclear receptor response element;
NSCLC, non-small-cell lung;
NeG, 1,N2-etheno-dGuo;
OPC, oropharyngeal cancer;
OS, overall survival;
OvCa, ovarian cancer;
PBMC, peripheral blood mononuclear cell;
PC, pancreatic cancer;
PdG, N2-propano-2′-deoxyguanosine;
Polymorphism;
Progression;
REV1, Y-family DNA polymerase;
SCC, squamous cell carcinoma;
TGF-β, transforming growth factor β;
Tumorigenesis;
VHL, von Hippel-Lindau;
ccRCC, clear-cell renal cell carcinomas;
εPKC, epsilon protein kinase C
- From:
Acta Pharmaceutica Sinica B
2021;11(6):1400-1411
- CountryChina
- Language:English
-
Abstract:
A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and tumorigenesis/growth/metastasis has been widely reported. Either low or high ALDH2 expression contributes to tumor progression and varies among different tumor types. Furthermore, the ALDH2∗2 polymorphism (rs671) is the most common single nucleotide polymorphism (SNP) in Asia. Epidemiological studies associate ALDH2∗2 with tumorigenesis and progression. This study summarizes the essential functions and potential ALDH2 mechanisms in the occurrence, progression, and treatment of tumors in various types of cancer. Our study indicates that ALDH2 is a potential therapeutic target for cancer therapy.
