Discovery of alkaloids from the leaves of Isatis indigotica Fortune with neuroprotective activity.
10.1016/S1875-5364(21)60093-6
- Author:
Yu-Fei XI
1
;
Li-Li LOU
2
;
Feng-Ying HAN
1
;
Xiao-Bo WANG
3
;
Xiao-Xiao HUANG
4
,
5
;
Guo-Dong YAO
6
;
Shao-Jiang SONG
5
,
7
Author Information
1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Chinese People's Liberation Army Logistics Support Force No.967 Hospital, Dalian 116000, China.
3. Chinese People's Liberation Army Logistics Support Force No.967 Hospital, Dalian 116000, China.
4. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: xiaoxiao270@
5. com.
6. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: 604520368@qq.com.
7. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: songsj99@
- Publication Type:Journal Article
- Keywords:
Alkaloids;
Isatis indigotica;
Neuroprotective effects;
Structure elucidation
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(9):680-685
- CountryChina
- Language:English
-
Abstract:
Seven alkaloids including five undescribed ones (1a/1b, 2, 3 and 5) were obtained from the leaves of Isatis indigotica Fortune. Their structures were established by extensive spectroscopic analyses. The absolute configurations of compounds 1a, 1b, 3 and 5 were determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Subsequently, the neuroprotective effects of all the isolates against H
