Research Advances in the Mechanisms of BRD4 and Its Inhibitors in Hematologic Malignancies--Review.
10.19746/j.cnki.issn.1009-2137.2021.04.057
- Author:
Ri-Li GAO
1
;
Cheng-Wu ZENG
2
,
3
;
Yang-Qiu LI
3
,
4
Author Information
1. Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
2. Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China,E-mail: bio-zcw@
3. com.
4. Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China,E-mail: jnyangqiuli@
- Publication Type:Review
- MeSH:
Cell Cycle Proteins;
Cell Proliferation;
Hematologic Neoplasms/drug therapy*;
Humans;
Nuclear Proteins;
Protein Domains;
Transcription Factors
- From:
Journal of Experimental Hematology
2021;29(4):1365-1368
- CountryChina
- Language:Chinese
-
Abstract:
Bromodomain-containing protein 4 (BRD4) is one of the most important members in the bromodomain and extra terminal domain(BET) family, it plays an important role in cellular physiology in human body, such as cell cycles, cell proliferation, and immune response. Recent studies have shown that BRD4 is associated with occurrence and development of acute myeloblastic leukemia, multiple myeloma and lymphoma. The mechanisms of BRD4 in hematologic malignancies including the regulation of c-Myc expression, and participation of the composition of super-enhancer, etc. At present, many kinds of inhibitors have been developed to target inhibit BRD4 for therapy in hematologic malignancies, and some of BRD4 inhibitors have entered phase Ⅱ clinical trials, which suggested that BRD4 inhibitors are expected to become new therapeutic agents for hematologic malignancies. In this review, the research advance of BRD4 and BRD4 inhibitors in hematologic malignancies was summarized briefly.
