Clinical Features and Prognosis of Patients with Hematological Disease Complicated with Mucor Infection.
10.19746/j.cnki.issn.1009-2137.2021.04.052
- Author:
Shu-Qin ZHANG
1
;
Hong-Xia WEN
1
;
Hai-Tao YU
2
;
Chang-Hai QI
3
;
Jing-Bo WANG
4
Author Information
1. Department of Hematology, Aerospace Center Hospital, Beijing 100049, China.
2. Department of Imaging, Aerospace Center Hospital, Beijing 100049, China.
3. Department of Pathology, Aerospace Center Hospital, Beijing 100049, China.
4. Department of Hematology, Aerospace Center Hospital, Beijing 100049, China,E-mail: dpwangjingbo@vip.sina.com.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Antifungal Agents/therapeutic use*;
Female;
Hematologic Diseases/complications*;
Humans;
Male;
Middle Aged;
Mucormycosis/drug therapy*;
Prognosis;
Retrospective Studies;
Young Adult
- From:
Journal of Experimental Hematology
2021;29(4):1340-1345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical features, treatment and prognosis of patients with hematological diseases complicated with mucor infection.
METHODS:The risk factors, clinical features, treatment regimen and prognosis of 18 hematological disease patients with mucor infection diagnosed by histopathology in our center from April 2014 to June 2020 were retrospectively analyzed.
RESULTS:Thirteen males and five females, with an average age of 30 (13－54) years old, were diagnosed as mucor infection by histopathological examination at the site of infection, including 16 cases of mucor infection alone and 2 cases of mucor + aspergillus mixed infection. There were 12 cases with malignant hematological disease and 6 cases with severe aplastic anemia, all of whom with long-term agranulocytosis, and their clinical manifestations and imaging findings were not specific. The common sites of infection were sinuses and lungs, and some patients showed multiple systemic manifestations. The remission status of hematological diseases and recovery of immune function showed an impact on the prognosis. All the patients were treated with amphotericin B liposome combined with posaconazole, and 15 patients were treated with surgery combined with antifungal drugs, 9 of whom were effective and 6 were ineffective, while intravenous administration in 3 cases was ineffective.
CONCLUSION:It is difficult to diagnose hematological disease complicated with mucor infection. After early diagnosis, prognosis can be improved by amelioration of primary state and combination of drugs and surgery.
