Retrospective Analysis of Serological Characteristics and Distribution of Patients with Mimicking Antibodies.
10.19746/j.cnki.issn.1009-2137.2021.04.045
- Author:
Yan-Nan FENG
1
;
Chun-Ya MA
1
;
Xin YANG
1
;
Ying WU
1
;
Chun-Yu HE
1
;
Yang YU
2
,
3
;
De-Qing WANG
4
Author Information
1. Department of Blood Transfusion, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
2. Department of Blood Transfusion, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China E-mail: yuyangpla301@
3. com.
4. Department of Blood Transfusion, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China E-mail: deqingw@vip.sina.com.
- Publication Type:Journal Article
- MeSH:
Autoantibodies;
Blood Group Antigens;
Blood Transfusion;
Female;
Humans;
Isoantibodies;
Pregnancy;
Retrospective Studies
- From:
Journal of Experimental Hematology
2021;29(4):1301-1307
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To understand the characteristics of patients with mimicking specificity autoantibodies through the analysis of the causes of autoantibodies, specificity of antibodies, strategy of blood transfusion, effect of transfusion and distribution of antibodies in China and abroad.
METHODS:A total of 23 patients who applied for blood in our hospital from January 2017 to June 2019 were identified as mimicking specificity autoantibodies by antibody identification or absorption-elution test. The causes of mimicking specificity autoantibodies, antibody specificity, blood transfusion strategy and blood transfusion effect were analyzed. The relevant articles on antibodies published in China and abroad were summarized and sorted out, and the distribution of antibodies was analyzed.
RESULTS:All the 23 patients with mimicking specificity autoantibodies were Rh blood group system antibodies, of which mimicking anti-Ce autoantibodies were the most common (34.8%), followed by mimicking anti-e autoantibodies (26.1%), mimicking anti-D autoantibodies (21.7%), mimicking anti-C autoantibodies (8.7%) and mimicking anti-E autoantibodies (8.7%). Except for 2 cases with suspected history of blood transfusion, the other 21 cases had a history of blood transfusion / pregnancy. The most common cause of mimicking autoantibodies was drug, followed by infection and autoimmune diseases. The hemoglobin (Hb) of pretransfusion in the blood transfusion group was (48.4±23.9) g/L, which was significantly lower than (86.0±38.9) g/L in the non-transfusion group (P<0.01). Except for 2 cases who could not evaluate the effect of blood transfusion, the effective rate of transfusion was 100%. According to the retrospective statistics of 32 related articles published in China and abroad, the most type of mimicking antibodies were in Rh blood group system, accounting for 79.28%, among which anti-E was the main part of all mimicking autoantibodies, accounting for 21.95%. The following ones were in Kidd system MNSs system, and Kell system.
CONCLUSION:Combined with the clinical symptoms and the degree of difficulty of blood matching, the best strategy of blood transfusion should be selected to ensure the safety of blood transfusion.
