Assessing Liver Function by T1 Maps on Gd-EOB-DTPA-Enhanced MRI for up to 50 Min in Rat Models of Liver Fibrosis: A Longer Hepatobiliary Time Period may Help.

Author: Jia XU ¹ ; Xuan WANG ¹ ; Zheng Yu JIN ¹ ; Qin WANG ¹ ; Yan YOU ² ; Shi Tian WANG ¹ ; Tian Yi QIAN ³ ; Hua Dan XUE ¹
Author Information

1. Department of Radiology,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
2. Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
3. Siemens Healthcare Ltd., Beijing 100102, China.
Publication Type:Journal Article
From: Chinese Medical Sciences Journal 2021;36(2):110-119
CountryChina
Language:English
Abstract: Objectives To investigate whether a longer time period of gadolinium ethoxybenzyl diethylenetriaminepen-taacetic acid (Gd-EOB-DTPA)-enhanced T1 mapping scanning, as well as dynamic contrast-enhanced (DCE) and multiple hepatobiliary phase magnetic resonance imaging (MRI) have the potential to provide information about liver function in rats with liver fibrosis. Methods Forty rats were divided into the carbon tetrachloride-induced hepatic injury groups [carbon tetrachloride for four (