Analysis of animal models of stable chronic obstructive pulmonary disease based on clinical features of traditional Chinese medicine and western medicine.
10.19540/j.cnki.cjcmm.20210609.703
- Author:
Lei LI
1
;
Chun-Lei LI
2
;
Hui-Zhuo SUN
1
;
Yue YAN
2
;
Qi SHI
2
;
Dong-Xu SI
1
;
Dong-Liang WU
1
;
You-Lin LI
2
Author Information
1. Beijing University of Chinese Medicine Beijing 100029, China the 2nd Department of Pulmonary Disease, China-Japan Friendship Hospital, Key Unit of State Administration of Traditional Chinese Medicine (Pneumonopathy Chronic Cough and Dyspnea),Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases with Traditional Chinese Medicine (BZ0321),Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases Beijing 100029, China.
2. the 2nd Department of Pulmonary Disease, China-Japan Friendship Hospital, Key Unit of State Administration of Traditional Chinese Medicine (Pneumonopathy Chronic Cough and Dyspnea),Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases with Traditional Chinese Medicine (BZ0321),Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases Beijing 100029, China.
- Publication Type:Journal Article
- Keywords:
animal model;
chronic obstructive pulmonary disease(COPD);
stable phase;
the features of clinical disease-syndrome
- MeSH:
Animals;
Disease Models, Animal;
Drugs, Chinese Herbal;
Humans;
Medicine;
Medicine, Chinese Traditional;
Models, Animal;
Pulmonary Disease, Chronic Obstructive/drug therapy*;
Syndrome
- From:
China Journal of Chinese Materia Medica
2021;46(17):4575-4580
- CountryChina
- Language:Chinese
-
Abstract:
This study analyzed the advantages and disadvantages of existing animal models in China and abroad and their goodness of fit based on the clinical characteristics and diagnostic criteria of stable chronic obstructive pulmonary disease(COPD) in traditional Chinese medicine(TCM) and western medicine, followed by the collation and summarization of model evaluation methodologies. The results showed that the existing animal models of stable COPD were mainly modeled via smoke exposure or the combination of multiple methods like smoke exposure plus lipopolysaccharide or protease or bacterial infection. These animal models generally failed to simulate the clinical characteristics of TCM, and their goodness of fit in western medicine was higher than that in TCM. There is a lack of research on the animal models of stable COPD and the disease-syndrome combination models. Although the modeling is guided by the pathogenesis or mechanism of diseased humans, the established models were still not identical with the actual clinical situations. In-depth research is needed to develop quantitative standards for stable COPD models.
