Exploring efficacy of Chinese medicine injection for promoting blood circulation and removing blood stasis in treatment of acute cerebral infarction based on two complex network analysis methods.
10.19540/j.cnki.cjcmm.20201209.501
- Author:
Rui-Xue HU
1
;
Dan-Dan YU
1
;
Hui-Min LI
1
;
Hao GU
2
;
Hui ZHAO
3
;
Hai-Yu XU
4
;
Bing LI
5
;
Jing HU
6
;
Xing LIAO
1
Author Information
1. Center for Evidence-based Chinese Medicine,Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
2. Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
3. China Center for Evidence-based Traditional Chinese Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
4. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
5. Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
6. Beijing Hospital of Traditional Chinese Affiliated to Capital Medical University,Beijing Institute of Chinese Medicine Beijing 100010,China.
- Publication Type:Meta-Analysis
- Keywords:
Danhong Injection;
Mailuoning Injection;
acute cerebral infarction;
network Meta-analysis;
network pharmacology
- MeSH:
Cerebral Infarction/drug therapy*;
Drugs, Chinese Herbal/therapeutic use*;
Endothelial Cells;
Female;
Humans;
Injections;
Medicine, Chinese Traditional;
Pregnancy;
Signal Transduction
- From:
China Journal of Chinese Materia Medica
2021;46(14):3722-3731
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to explore the efficacy of Chinese medicine injections( CMIs) for promoting blood circulation and removing blood stasis for acute cerebral infarction from the perspectives of clinical medication and mechanism of action based on two complex network analysis methods. Firstly,the current 13 kinds of CMIs for acute cerebral infarction were obtained from 2019 List of medicines for national basic medical insurance,industrial injury insurance and maternity insurance with the method of network Meta-analysis. Secondly,with the use of network pharmacology,the mechanisms of top 2 CMIs with the highest therapeutic effect for acute cerebral infarction were explored from two levels including core target and network function enrichment. The result of network Meta-analysis showed Mailuoning Injection was superior to Danhong Injection in terms of total effectiveness rate for neurological deficit score and NIHSS score. The network pharmacology results showed that Mailuoning Injection had more core targets,interaction networks,enriched biological functions and more signaling pathways than Danhong Injection for cerebral infarction. Both two CMIs can play a role in treating cerebral infarction through core targets such as TP53 and NOS3,biological processes such as fibrinolysis,nitric oxide biosynthesis,nitric oxide-mediated signal transduction,negative regulation of apoptosis in endothelial cells and apoptosis process,as well as the signaling pathways such as PI3 K-Akt signaling pathway,HIF-1 signaling pathway and cell apoptosis signaling pathways. The results of pharmacological studies explained their differences in clinical efficacy to a certain extent. A research strategy based on curative effect should be advocated in efficacy evaluation of traditional Chinese medicine,where comparative research on clinical efficacy can be conducted firstly,and then mechanism research based on outstanding effective drugs to better provide references and basis for selection of similar competitive drugs for one disease in the clinical practice.
