Review of chemical constituents,pharmacological effects and clinical applications of Danggui Buxue Decoction and prediction and analysis of its Q-markers.
10.19540/j.cnki.cjcmm.20200828.201
- Author:
Fei-Xia YANG
1
;
Yu WANG
1
;
Peng-Fei XIA
2
;
Rui-Jing YANG
3
;
Yu-Xia WANG
1
;
Jian ZHANG
1
;
Qin FAN
1
;
Lei ZHAO
2
Author Information
1. Gansu University of Chinese Medicine Lanzhou 730000,China.
2. Gansu University of Chinese Medicine Lanzhou 730000,China Key Laboratory of Chemistry and Quality for Traditional Chinese Medicines of Colleges of Gansu Province,Gansu University of Chinese Medicine Lanzhou 730000,China Gansu Province Engineering Laboratory for Traditional Chinese Medicine Standardization Technology and Popularization Lanzhou 730000,China.
3. Gansu University of Chinese Medicine Lanzhou 730000,China Qingyang Women and Children's Hospital Qingyang 745000,China.
- Publication Type:Review
- Keywords:
Danggui Buxue Decoction;
Q-marker;
chemical constituents;
clinical application;
pharmacological effects
- MeSH:
Astragalus Plant;
Drugs, Chinese Herbal/pharmacology*;
Plant Roots
- From:
China Journal of Chinese Materia Medica
2021;46(11):2677-2685
- CountryChina
- Language:Chinese
-
Abstract:
Danggui Buxue Decoction is a classic prescription of Qi and blood tonification, which is mainly applied in treating fatigue, internal damage Qi weakness, blood deficiency, and outward going of floating Yang. Modern pharmacology shows that it can promote hematopoiesis, regulate immunity, and protect heart and cerebral vessels. The prescription, often used for the treatment of anemia and other diseases in clinic, is composed of Astragali Radix and Angelicae Sinensis Radix at a dosage ratio of 5∶1. It is a modern compound prescription for invigorating Qi and generating blood. Based on the review of the chemical constituents, pharmacological effects, and clinical applications of Danggui Buxue Decoction, its Q-marker was predicted and analyzed according to the "five principles" of Chinese medicine Q-marker--quality transmissibility and traceability, ingredient specificity, component validity, component measurabi-lity, and formula compatibility environment. The results suggested that calycosin, calycosin-7-O-β-D-glucoside, formononetin, ononin, astragaloside A, ferulic acid, and ligustilide could be used as Q-markers of Danggui Buxue Decoction, which provides reference for establishing the quality system of Danggui Buxue Decoction.
