Evaluation of drug myocardial toxicity and biological activity by real time xCELLigence analysis: a review.

Author: Xu ZHANG ¹ ; Ruiying WANG ² ; Rongchang CHEN ² ; Lijiao XU ¹ ; Xiaobo SUN ² ; Miao YU ¹ ; Guibo SUN ²
Author Information

1. Engineering Research Center for Medicine, College of Pharmacy, Harbin University of Commerce, Harbin 150076, Heilongjiang, China.
2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China.
Publication Type:Review
Keywords: RTCA; biological activity; cell detection; drug research; myocardial toxicity
MeSH: Pharmaceutical Preparations
From: Chinese Journal of Biotechnology 2021;37(7):2425-2434
CountryChina
Language:Chinese
Abstract: Realtime xCELLigence analysis (RTCA) is a new cell detection technology to continuously monitor, record and analyze a variety of information generated by cell activity. In drug research, it plays an important role in assessing myocardial toxicity and cell biological activity. Here, we first introduce the underlying mechanisms and characteristics of RTCA. Then we review the applications of RTCA in the research of myocardial toxicity and cell biological activity, to provides the fundamental baseline for understanding and exploiting RTCA. With the real-time, unlabeled, non-invasive, high throughput, and high accuracy features, RTCA not only promotes drug research and development, but also has a broad and good application prospect in other fields.