Expression of Ki-67, Cyclin D1, P53, and P16 in patients with oral leukoplakia and leukoplakia cancerization with spicy diet in Chengdu.
- Author:
Zi-Xin WAN
1
;
Zhi-Jian ZHENG
1
;
Mei-Chang HUANG
1
;
Yu CHEN
1
;
Li-Hong YAO
1
Author Information
- Publication Type:Journal Article
- Keywords: cancerization; oral leukoplakia; oral potentially malignant disorders; spicy diet
- MeSH: Carcinoma, Squamous Cell; Cyclin D1; Diet; Head and Neck Neoplasms; Humans; Ki-67 Antigen; Leukoplakia, Oral; Mouth Neoplasms; Tumor Suppressor Protein p53
- From: West China Journal of Stomatology 2021;39(4):434-440
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To investigate the expression of Ki-67, Cyclin D1, P53, and P16 in patients with oral leukoplakia (OLK) and OLK cancerization who have aspicy diet in Chengdu.
METHODS:Thirtypatients with OLK andspicy diet and 15 patients with OLK without spicy diet in Chengdu were divided into three groups: hyperplastic OLK (OLK-), OLK with mild to moderate dysplasia (OLK+), and severe dysplastic OLK or oral squamous cell carcinoma (OSCC) transforming from OLK (OLK++/OSCC). The expression of Ki-67, Cyclin D1, P53, and P16 were detected by immunohistochemistry and statistically analyzed.
RESULTS:The expression of Ki-67 and P53 in patients with or without spicy diet in the OLK+and OLK++/OSCC groups were stronger than that of the OLK- group (
CONCLUSIONS:Spicy diet did not have an influence on the expression of Ki-67, Cyclin D1, P53, and P16 in patients with OLK and OSCC. The expression of Ki-67, Cyclin D1, and P53 increased with the development of OLK, whereas P16 showed opposite expression trend.
