Chemical composition and hypoglycemic activity of Edgeworthia gardneri
10.16438/j.0513-4870.2020-1970
- VernacularTitle:藏药绿萝花化学成分及其降糖活性研究
- Author:
Jie-xue WANG
1
;
Guo TAO
1
;
Fan YANG
1
;
Min YANG
1
;
Qing-qin FENG
1
;
Ming-fang MA
2
;
Jing CHEN
3
Author Information
1. College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu 611130, China
2. Qinghai Province Institute for Food Control, Xining 810008, China
3. Tibet University of Tibetan Medicine, Lhasa 850000, China
- Publication Type:Research Article
- Keywords:
Tibetan material herb;
italic>Edgeworthia gardneri;
edgeworthiaside A;
italic>α-glucosidase;
chemical constituent
- From:
Acta Pharmaceutica Sinica
2021;56(5):1434-1438
- CountryChina
- Language:Chinese
-
Abstract:
Seven compounds were isolated from the alcohol extract of Edgeworthia gardneri by various technologies, including silica gel, Sephadex LH-20 and high performance liquid chromatography, and were identified as edgeworthiaside A (1), 2,4,6-trichlorol-3-methyl-5-methoxy-phenol 1-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranoside (2), 2,6-dimethoxy-4-(2-propen-1-yl)phenyl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside (3), eugenol rutinoside (4), tiliroside (5), edgeworoside C (6), and salicylic acid (7). Compound 1 is a new chlorophenyl glycoside and 2-4 were isolated for the first time from Edgeworthia gardneri. The in vitro inhibition of α-glucosidase showed that the inhibition rate of compounds 1 and 2 were similar to acarbose.
