Application of environmentally sensitive hydrogels in drug delivery
10.16438/j.0513-4870.2020-1873
- VernacularTitle:环境敏感型水凝胶在药物递送中的应用
- Author:
Yuan-yuan ZHANG
1
;
Li-na DU
1
;
Yi-guang JIN
2
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250355, China; Beijing Institute of Radiation Medicine, Beijing 100850, China
2. Beijing Institute of Radiation Medicine, Beijing 100850, China
- Publication Type:Research Article
- Keywords:
temperature-sensitive hydrogel;
pH-sensitive hydrogel;
enzyme-sensitive hydrogel;
administration route;
polymer;
environmentally sensitive
- From:
Acta Pharmaceutica Sinica
2021;56(5):1314-1331
- CountryChina
- Language:Chinese
-
Abstract:
Environmentally sensitive hydrogels are a novel formulation that has developed rapidly in recent years. It could form semi-solid with good adhesion in the topical sites based on different physiological environments. Its long local retention time is conducive for sustained drug release, and the preparation process is relatively simple and easy to realize industrialization. This review summarized the categories, commonly used polymer, and different administration routes based on the recently published literatures. According to different response factors, it can be divided into temperature, pH, ion, light, and multiple sensitive hydrogels, among which temperature-sensitive hydrogels are the most common. The most commonly used polymers include chitosan, poly N-isopropyl acrylamide, and poloxamer. There are different administration routes for environmentally sensitive hydrogels, such as transdermal, ophthalmic, nasal, oral, vaginal, rectal, injection, etc. Environmentally sensitive hydrogels have broad prospects in clinical application.
