Tert-butanol application and related research progress in biomedicine
10.16438/j.0513-4870.2021-0785
- VernacularTitle:叔丁醇在生物医药领域的主要应用及研究进展
- Author:
Hong-liang WANG
1
;
Wu-jun DONG
2
;
Lei CHEN
3
;
Jun YE
1
;
Yan-bao WANG
1
;
Yu-ling LIU
1
Author Information
1. Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
2. Center for Drug Evaluation, National Medical Products Administration, Beijing 100038, China
3. Chinese Pharmacopoeia Commission, Beijing 100061, China
- Publication Type:Research Article
- Keywords:
italic>tert-butanol;
pharmaceutical preparation;
poorly water-soluble drug;
freeze drying;
safety
- From:
Acta Pharmaceutica Sinica
2021;56(9):2513-2521
- CountryChina
- Language:Chinese
-
Abstract:
italic>Tert-butanol is an organic solvent, widely used in the medical field and chemical industry. It could be characterized by high crystallization temperature and vapor pressure. It could be easily sublimed and removed during the freeze-drying process. This review mainly describes the use of tert-butanol in the lyophilized formulations of poorly soluble drugs, the lyophilization solvent of porous structure productions, and as an ice crystal growth guider. In addition, the application of tert-butanol in nano drugs and aerogels has also been reviewed, as well as the current research progress in its quality and safety.
