The therapeutic effect of budesonide on childhood asthma and its influence on growth and development 1 to 2 years after the treatment
10.12206/j.issn.1006-0111.202101013
- VernacularTitle:儿童哮喘辅以布地奈德的治疗效果及其用药后1～2年对生长发育的影响
- Author:
Xiuli HAO
1
;
Fang XIE
2
;
Xueping YAN
1
Author Information
1. Beijing First Integrated Hospital of Chinese and Western Medicine, Beijing 100018, China..
2. Institute of Hepatology, Beijing You′An Hospital Affliated to Capital Medical University, Beijing 100018, China.
- Publication Type:Medicine&Clinical
- Keywords:
regulatory B cells;
acute asthma attack in children;
salbutamol sulfate inhalation aerosol;
budesonide suspension for inhalation;
growth and development
- From:
Journal of Pharmaceutical Practice
2021;39(5):479-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of budesonide suspension for inhalation in the treatment of childhood asthma and its influence on growth and development in 1-2 years. Methods The 68 children with asthma admitted to our hospital from October 2016 to January 2017 were selected. Every patient had acute attacks and received continued medication. 34 patients treated with salbutamol sulfate inhaled aerosol were used as the control group. 34 patients treated with budesonide suspension combined with salbutamol sulfate aerosol were classified as the observation group. The interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), high-sensitivity-C-reactive protein (hs-CRP), maximum respiratory flow, IS maximum expiratory volume, regulatory B cell ratio, wheezing disappearance time, shortness of breath relief time, wet rales disappearing time, cough disappearing time, and the two year follow-up indicators of growth and development were compared. Results After medication, IL-6, TNF-α, hs-CRP, regulatory B cell ratio, wheezing disappearance time, shortness of breath relief time, moist rales disappearance time, and cough disappearance time were lower in the observation group(P<0.05). The maximum respiratory flow and IS maximum expiratory volume in the observation group were higher than those in the control group (P<0.05). The GH level, height, and weight obtained from two year follow up in the observation group were lower than those in the control group (P<0.05). Conclusion Budesonide suspension combined with salbutamol sulfate aerosol inhalation therapy can alleviate the inflammatory reaction, improve the lung function and immune function of children, and accelerate the disappearance of clinical symptoms, but it will affect the growth and development of children to a certain extent.
