A smart MnO
10.1016/j.apsb.2020.07.021
- Author:
Peng LIU
1
;
Xin XIE
2
;
Miao LIU
1
;
Shuo HU
3
;
Jinsong DING
1
;
Wenhu ZHOU
1
Author Information
1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
2. School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, China.
3. Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- Keywords:
Cisplatin;
GSH depletion;
Nanoparticles;
Nanozyme;
Oxygenation;
Photosensitizer;
Targeting;
Tumor microenvironment
- From:
Acta Pharmaceutica Sinica B
2021;11(3):823-834
- CountryChina
- Language:English
-
Abstract:
The combination of chemotherapy and photodynamic therapy provides a promising approach for enhanced tumor eradication by overcoming the limitations of each individual therapeutic modality. However, tumor is pathologically featured with extreme hypoxia together with the adaptable overexpression of anti-oxidants, such as glutathione (GSH), which greatly restricts the therapeutic efficiency. Here, a combinatorial strategy was designed to simultaneously relieve tumor hypoxia by self-oxygenation and reduce intracellular GSH level to sensitize chemo-photodynamic therapy. In our system, a novel multi-functional nanosystem based on MnO
