Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder.
10.1016/j.apsb.2020.11.012
- Author:
Pei WANG
1
;
Fang WANG
1
;
Lan NI
1
;
Pengfei WU
1
;
Jianguo CHEN
1
Author Information
1. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
- Publication Type:Review
- Keywords:
AAMI, age-associated memory impairment;
AD, Alzheimer's disease;
AMPARs, α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptors;
CaMKII, Ca2+/calmodulin-dependent protein kinase II;
Cognitive disorder;
DG, dentate gyrus;
DS, Down syndrome;
DTNB, 5,5-dithio-bis-2-nitrobenzoic acid;
DTT, dithiothreitol;
EPSPs, excitatory postsynaptic potentials;
GSK-3β, glycogen synthase kinase-3β;
Glu, glutamate;
H2O2, hydrogen peroxide;
HFS, high-frequency stimulation;
Hydrogen sulfide;
LFS, low-frequency stimulation;
LTD, long-term depression;
LTP, long-term potentiation;
Learning and memory;
Long-term potentiation;
MF, mossy fiber;
N-Methyl-d-aspartate receptor;
NAC, N-acetyl cysteine;
NADPH, nicotinamide adenine dinucleotide phosphate;
NMDARs, N-methyl-d-aspartate receptors;
NO, nitric oxide;
Oxidative stress;
PTM, posttranslational modification;
ROS, reactive oxygen species;
Reactive oxygen species;
SC, Schaffer collateral;
SNOC, S-nitrosocysteine;
Synaptic plasticity;
TFAM, mitochondrial transcription factor A;
VD, vascular dementia
- From:
Acta Pharmaceutica Sinica B
2021;11(3):599-608
- CountryChina
- Language:English
-
Abstract:
Redox-altered plasticity refers to redox-dependent reversible changes in synaptic plasticity
