HIF
10.11817/j.issn.1672-7347.2021.200010
- Author:
Wen TANG
1
,
2
;
Tingting LONG
3
;
Fangfang LI
3
;
Cong PENG
3
;
Shuang ZHAO
3
;
Xiang CHEN
3
;
Juan SU
3
,
4
Author Information
1. Department of Geriatrics, Xiangya Hospital, Central South University, Changsha
2. 465743753@qq.com.
3. Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha
4. sujuanderm@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
CD147;
glucose transporter 1;
glycolysis;
hypoxia-inducible factor-1α;
psoriasis
- MeSH:
Basigin;
Glucose Transporter Type 1;
Glycolysis;
Humans;
Hypoxia-Inducible Factor 1, alpha Subunit/genetics*;
Psoriasis/genetics*;
Transcriptional Activation;
Up-Regulation
- From:
Journal of Central South University(Medical Sciences)
2021;46(4):333-344
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To analyze the expressions and distributions of hypoxia-inducible factor-1α (HIF-1α), CD147, and glucose transporter 1 (GLUT1) in epidermis from psoriasis vulgaris and normal people, and to explore the associations among these proteins and their roles in hypoxic HaCaT cell line.
METHODS:The expression levels of HIF-1α, CD147, and GLUT1 were determined by immunohistochemistry staining in skin biopsies from 48 psoriasis vularis patients and 33 healthy subjects. Cobalt chloride (CoCl
RESULTS:HIF-1α, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1α upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl
CONCLUSIONS:Glycolytic capacity increases in the injured keratinocytes of psoriasis vulgaris, suggesting that HIF-1α, CD147, and GLUT1 are associated with glycolysis, which can be considered as the promising targets for psoriasis therapy.
