Clinical significance of PD
10.11817/j.issn.1672-7347.2020.190101
- Author:
Junmi LU
1
,
2
;
Juan FENG
3
;
Hongmei ZHENG
1
;
Qiuyuan WEN
1
;
Songqing FAN
1
,
4
Author Information
1. Department of Pathology, Second Xiangya Hospital, Central South University, Changsha
2. 1136980635@qq.com.
3. Department of Laboratory, Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha 410007, China.
4. songqingfan@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
molecular marker;
non-small cell lung cancer;
prognosis;
programmed cell death- ligand 1
- MeSH:
Adenocarcinoma of Lung;
B7-H1 Antigen/genetics*;
Biomarkers, Tumor;
Carcinoma, Non-Small-Cell Lung/surgery*;
Humans;
Lung Neoplasms/surgery*;
Patients;
Prognosis
- From:
Journal of Central South University(Medical Sciences)
2020;45(10):1149-1154
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To explore the expression of programmed death ligand-1 (PD-L1) as well as the correlation between the expression and the clinicopathological features or prognosis in non-small cell lung cancer (NSCLC).
METHODS:The expression of PD-L1 protein in 254 cases of surgically resected lung adenocarcinoma (L-ADC), 228 cases of surgically resected lung squamous cell cancer (L-SCC), and 99 cases of non-cancerous control lung tissues was detected with immunohistochemical SP method. The correlation between the PD-L1 expression and clinicopathological features was analyzed. Kaplan-Meier univariate and Cox multivariate regression analyses were performed to assess the prognosis of patients with L-ADC and L-SCC, respectively.
RESULTS:Positive percentage of PD-L1 protein expression was higher in the tissues of L-ADC and L-SCC than that in the non-cancerous control lung tissues respectively (both
CONCLUSIONS:The positive percentage of PD-L1 protein expression is higher in the L-SCC patients than that in the L-ADC patients. Positive expression of PD-L1 protein can be served as an independent prognostic factor of poor prognosis in the patients with L-ADC.
